MECHANISM ON DISORDERS OF COAGULATION AND FIBRINOLYSIS IN DIABETES

Determination of various important parameters of coagulation and fibri nolysis, clinical characteristics, and levels of serum lipid were comp ared in 193 patients with NIDDM and 50 control subjects. Levels of fib rinogen, tissue factor pathway inhibitor (TFPI), thrombin-antithrombin complex, and plasminogen activator inhibitor 1 in plasma increased si gnificantly in the diabetic patients. Levels of TFPI correlated signif icantly with levels of total cholesterol. In the patients with coronar y heart disease or cerebral. infarction, levels of lipoprotein(a) incr eased significantly. From these results, we have concluded that there is a thrombotic tendency or at least an imbalance between the hemostat ic and thrombosis-protecting system in diabetic patients, especially i n patients with angiopathy.