PALLADIUM-CATALYZED CROSS-COUPLING OF 7-IODO-2'-DEOXYTUBERCIDIN WITH TERMINAL ALKYNES

Authors
SEELA F ZULAUF M
Citation
F. Seela et M. Zulauf, PALLADIUM-CATALYZED CROSS-COUPLING OF 7-IODO-2'-DEOXYTUBERCIDIN WITH TERMINAL ALKYNES, Synthesis, (6), 1996, pp. 726
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
6
Year of publication
1996
Database
ISI
SICI code
0039-7881(1996):6<726:PCO7WT>2.0.ZU;2-9
Abstract
The 7-alkynyl-2'-deoxytubercidins (7-deaza-2'-deoxyadenosines) 7-17 ha ve been prepared by the Pd(O)/Cu(I)-catalyzed cross coupling of 7-iodo -2'-deoxytubercidin (2d) with terminal alkynes. The coupling products include 17 alpha-ethynyltestosterone and 17 alpha-ethynylestradiol der ivatives (16, 17).