Background: The purpose of this study was to design and implement a co
mprehensive infection control program and measure its effects on the n
umber and types of infectious illnesses experienced by children attend
ing a specialized preschool program. Methods: Participants in the stud
y were children with Down syndrome enrolled in a school-based early in
tervention program. The ages of the children ranged from 6 weeks to 5
years. Through a series of parental questionnaires, the number and typ
es of infections in the children were chronicled for a year before and
a year after the implementation of an infection control intervention
program. Interventions included infection control lectures, handouts,
posters, and attention to environmental cleaning and disinfection, wit
h an emphasis on toys. Compliance with these measures was monitored an
d recorded. Results: During the interventional year the median number
of total illnesses/child/month decreased significantly from the baseli
ne year (0.70 vs 0.53, p < 0.05), with a trend toward a decrease in th
e number of respiratory illnesses (0.67 vs 0.42, p < 0.07). Significan
t decreases were also seen for the median number of physician visits (
0.50 vs 0.33, p < 0.05), courses of antibiotics administered (0.33 vs
0.28, p < 0.05), and days of school missed as a result of respiratory
illness (0.75 vs 0.40, p < 0.05). Conclusions: This study demonstrates
a decrease in infection rates with the implementation of a comprehens
ive educational and environmental infection control program in a day c
are setting.