GSH TRANSPORTERS - MOLECULAR CHARACTERIZATION AND ROLE IN GSH HOMEOSTASIS

Considerable progress has been made in the last few years in the molec ular identification and characterization of hepatic GSH transporter-as sociated polypeptides. We are now poised to determine their precise me chanisms of action and regulation at the transcriptional and post-tran slational level. It is also anticipated that molecular characterizatio n of the mitochondrial GSH transporter and sodium GSH co-transporters will be accomplished in the near future. With this information, a more complete understanding of GSH/cysteine homeostasis can be achieved wh ich can be applied to furthering the prevention and treatment of the d iseases of oxidative stress, such as aging, HIV, cataract, atheroscler osis, cancer and alcoholic liver disease.