N. Kaplowitz et al., GSH TRANSPORTERS - MOLECULAR CHARACTERIZATION AND ROLE IN GSH HOMEOSTASIS, Biological chemistry Hoppe-Seyler, 377(5), 1996, pp. 267-273
Considerable progress has been made in the last few years in the molec
ular identification and characterization of hepatic GSH transporter-as
sociated polypeptides. We are now poised to determine their precise me
chanisms of action and regulation at the transcriptional and post-tran
slational level. It is also anticipated that molecular characterizatio
n of the mitochondrial GSH transporter and sodium GSH co-transporters
will be accomplished in the near future. With this information, a more
complete understanding of GSH/cysteine homeostasis can be achieved wh
ich can be applied to furthering the prevention and treatment of the d
iseases of oxidative stress, such as aging, HIV, cataract, atheroscler
osis, cancer and alcoholic liver disease.