PALLADIUM(II) COMPLEXES OF DIALKYL ALPHA-ANILINOBENZYLPHOSPHONATES - SYNTHESIS, CHARACTERIZATION, AND CYTOSTATIC ACTIVITY

The new palladium(II) halide complexes with diethyl and dibutyl esters of (alpha-anilino-N-benzyl)phosphonic acid and diethyl and dibutyl es ters of [alpha-(4-benzeneazoanilino)-N-benzyl]phosphonic acid have bee n prepared and studied. All organophophorus ligands form dihalide comp lexes, trans-Pd(L)(2)X(2) (X = Cl or Br), with monodentate N-bonded li gand through the anilinobenzyl nitrogen in (alpha-anilino-N-benzyl)pho sphonate complexes and through the azo nitrogen in [alpha-(4-benzeneaz oanilino)-N-benzyl]phosphonate complexes, respectively, without partic ipation of the phosphoryl group. Azobenzene containing ligands by orth o-metallation also form binuclear organo-palladium complexes, [Pd(L-H) Cl](2), with the metal-metal chloro bridge. The complexes have been id entified and characterized by elemental analysis, infrared and H-1 NMR , as well as by magnetic and conductometric measurements. All were tes ted in vitro for their cytostatic activity against KB and L1210 tumor cell lines. The results show that these complexes inhibit the multipli cation of these tumor cells, but only the dichloro adduct of diethyl [ alpha-(4-benzeneazoanilino)-N-benzyl]phosphonate was found to have act ivity comparable to that of the antitumor drug cisplatin.