STRUCTURAL BASIS FOR SPECIFICITY OF GRB2-SH2 REVEALED BY A NOVEL LIGAND-BINDING MODE

Authors
RAHUEL J GAY B ERDMANN D STRAUSS A GARCIAECHEVERRIA C FURET P CARAVATTI G FRETZ H SCHOEPFER J GRUTTER MG
Citation
J. Rahuel et al., STRUCTURAL BASIS FOR SPECIFICITY OF GRB2-SH2 REVEALED BY A NOVEL LIGAND-BINDING MODE, Nature structural biology, 3(7), 1996, pp. 586-589
Citations number
37
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
3
Issue
7
Year of publication
1996
Pages
586 - 589
Database
ISI
SICI code
1072-8368(1996)3:7<586:SBFSOG>2.0.ZU;2-5
Abstract
The complex of Grb2-SH2 a BCR-Abl target peptide reveals that the pept ide binds in a p-turn conformation; Trp 121 closes the binding site C- terminal to the phosphotyrosyl residue of the ligand and prevents it f rom assuming the expected extended conformation.