CORTICOBASAL DEGENERATION SYNDROME - A CASE OF LEWY BODY VARIANT OF ALZHEIMERS-DISEASE

Corticobasal degeneration syndrome (CBDS) is a well-described entity, although there are some cases in which clinical manifestations do not link with pathological findings. We present a 60-year-old man with a c linical course of CBDS. Postmortem examination demonstrated the featur es of the Lewy body variant of Alzheimer disease (LBVA). Different neu rological evaluations showed a progressive motor disorder with alien h and and parkinsonism affecting mainly the left side. His neuropsycholo gical examination was comparable with biparietal dysfunction, especial ly apraxias and signs of Gertsmann's syndrome. MRI and SPECT imaging r evealed parietal, temporal and occipital involvement. We conclude that the CBDS is a heterogeneous pathological entity.