The authors describe three patients with episodic cluster headache who
se attacks were all treated with subcutaneous sumatriptan. The patient
s described had a high frequency of attacks (more than two per day); t
herefore, far higher dosage of the drug was taken than commonly used i
n cluster headache. The patients did not experience any particular sid
e effects, neither during the treatment period nor on abrupt withdrawa
l of the drug. Moreover, neither tachyphylaxis nor addiction were obse
rved. The authors point out both the efficacy of sumatriptan, confirme
d in all the treated attacks, and its safety even at higher dosages th
an recommended.