FLUCONAZOLE IN CANDIDA-ALBICANS SEPSIS DURING PREGNANCY - CASE-REPORTAND REVIEW OF THE LITERATURE

Candida sepsis during pregnancy is a rare but life-threatening complic ation of infection with Candida albicans. In contrast to the situation with other antimicrobial agents, there exists only limited experience with systemic antifungal therapy during pregnancy. A recent report fo cuses on amphotericin B treatment in systemic fungal infection during pregnancy. The present report discusses a pregnant patient with Candid a albicans sepsis and endophthalmitis as well as candida infection of the oral and genital mucous membranes, after hyperalimentation and bro ad spectrum antibiotic therapy via a central venous catheter. The pati ent was treated with 10 mg/kg fluconazole from week 16 of gestation fo r a total duration of 50 days. Adverse effects did not occur and the r est of the pregnancy proceeded favourably for both the mother and the baby.