SUBSTITUENT EFFECT ON THE CHLORINATION OF 2-ALKOXYPYRIDINES TO GIVE 2-CHLOROPYRIDINES UNDER VILSMEIER-HAACK CONDITIONS

Authors
LAI LL LIN PY WANG JS HWU JR SHIAO MJ TSAY SC
Citation
Ll. Lai et al., SUBSTITUENT EFFECT ON THE CHLORINATION OF 2-ALKOXYPYRIDINES TO GIVE 2-CHLOROPYRIDINES UNDER VILSMEIER-HAACK CONDITIONS, Journal of chemical research. Synopses, (4), 1996, pp. 194-195
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Journal of chemical research. Synopses → ACNP
ISSN journal
03082342
Issue
4
Year of publication
1996
Pages
194 - 195
Database
ISI
SICI code
0308-2342(1996):4<194:SEOTCO>2.0.ZU;2-N
Abstract
Various substituted 2-alkoxypyridines were converted into the correspo nding 2-chloropyridines in 28-91% yields by use of POCl3 and DMF, in w hich the methyl, halogen, ester and nitro groups displayed an activati ng effect; in contrast, an amino group exhibited a deactivating effect .