THE PROBABLE ABSENCE OF INTRAMOLECULAR GENERAL BASE CATALYSIS IN THE HYDROLYSIS OF ETHYL 6-ETHYL-4-HYDROXY-CINNOLINE-3-CARBOXYLATE

Authors
BUTTON RG TAYLOR PJ
Citation
Rg. Button et Pj. Taylor, THE PROBABLE ABSENCE OF INTRAMOLECULAR GENERAL BASE CATALYSIS IN THE HYDROLYSIS OF ETHYL 6-ETHYL-4-HYDROXY-CINNOLINE-3-CARBOXYLATE, Journal of chemical research. Synopses, (5), 1996, pp. 218-219
Citations number
30
Categorie Soggetti
Chemistry
Journal title
Journal of chemical research. Synopses → ACNP
ISSN journal
03082342
Issue
5
Year of publication
1996
Pages
218 - 219
Database
ISI
SICI code
0308-2342(1996):5<218:TPAOIG>2.0.ZU;2-H
Abstract
Despite some formal resemblance to other cases where this can occur, t here is probably no intramolecular general base catalysis in the hydro lysis of the title compound; this may come about since the anionic cha rge is too diffuse, and because protonation would generate a disfavour ed tautomer.