ASYMMETRIC-SYNTHESIS .1. ENANTIOSELECTIVE CONJUGATE ADDITIONS OF GRIGNARD-REAGENTS TO CINNAMAMIDES DERIVED FROM N-METHYL, N-BUTYL AND N-BENZYL DERIVATIVES OF (R)-(-)-2-AMINOBUTAN-1-OL

The reaction of simple Grignard reagents with (R)-(-)-2-aminobutan-1-o l are shown to afford the corresponding conjugate adducts; acidic hydr olysis of these adducts yielded beta-phenylalkanoic acids with enantio meric excesses generally in the range 72-98%.