METHOD DEVELOPMENT FOR THE DETERMINATION OF CEFDINIR AND ITS RELATED SUBSTANCES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Authors
OKAMOTO Y ITOH K NAMIKI Y MATSUSHITA J FUJIOKA M YASUDA T
Citation
Y. Okamoto et al., METHOD DEVELOPMENT FOR THE DETERMINATION OF CEFDINIR AND ITS RELATED SUBSTANCES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, Journal of pharmaceutical and biomedical analysis, 14(6), 1996, pp. 739-748
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
14
Issue
6
Year of publication
1996
Pages
739 - 748
Database
ISI
SICI code
0731-7085(1996)14:6<739:MDFTDO>2.0.ZU;2-H
Abstract
The validation of the HPLC method used for the determination of cefdin ir and its related substances is described. The developed method was s pecific and stability-indicating and provided a linear response with c oncentration. The system and method precision, expressed as relative s tandard deviations, were not greater than 1%, and the reproducibilitie s within and between laboratories were acceptable for the assay method . The procedure can quantitate related substances greater than approxi mately 0.05% of the principal cefdinir peak.