MULTIPLE ENDOCRINE NEOPLASIA (MEN IIB) WITH CUSHINGS-SYNDROME DUE TO MEDULLARY-THYROID CARCINOMA PRODUCING CORTICOTROPIN-RELEASING HORMONE

Authors
TAGLIABUE M PAGANI A PALESTINI N MANIERI C MARTINA V
Citation
M. Tagliabue et al., MULTIPLE ENDOCRINE NEOPLASIA (MEN IIB) WITH CUSHINGS-SYNDROME DUE TO MEDULLARY-THYROID CARCINOMA PRODUCING CORTICOTROPIN-RELEASING HORMONE, Panminerva Medica, 38(1), 1996, pp. 41-44
Citations number
11
Categorie Soggetti
Medicine, General & Internal
Journal title
Panminerva Medica → ACNP
ISSN journal
00310808
Volume
38
Issue
1
Year of publication
1996
Pages
41 - 44
Database
ISI
SICI code
0031-0808(1996)38:1<41:MEN(IW>2.0.ZU;2-F
Abstract
We describe a case of Gushing's syndrome caused by a medullary thyroid carcinoma (MCT) secreting corticotropin-releasing-hormone (CRH) in a young woman presenting mucosal neuromas located on the top of the tong ue and eyelid areas. Laboratory studies showed, basally and after dexa methasone suppression test, serum cortisol and plasma pituitary cortic otrophin (ACTH) levels agreed with an ectopic Cushing's syndrome. Immu nohistochemical studies of the MCT tissue revealed a production of CRH and scattered cells containing vasopressin but not ACTH peptides. Thi s is the first demonstrated case of a CRH-secreting tumor in multiple endocrine neoplasia (MEN IIB) syndrome.