GRADIENT-ENHANCED ONE-DIMENSIONAL HETERONUCLEAR NOE EXPERIMENT WITH H-1 DETECTION

A new experiment, HETGOESY, is described in which C-13-H-1 NOE enhance ments are detected directly on H-1 The experiment uses pulsed field gr adients for coherence selection, thus completely avoiding the problems associated with difference spectroscopy. It is shown, both theoretica lly and experimentally, that the new experiment has sensitivity advant ages over the conventional C-13{H-1} steady-state NOE difference exper iment. The new experiment also has the advantage that it uses selectiv e excitation in the generally better resolved decoupled C-13 spectrum rather than the H-1 spectrum.