THERMOREGULATION AND THE PATHOGENESIS OF FEVER

Infections, trauma, inflammatory processes, and some malignant disease s induce a constellation of host responses that are collectively refer red to as the ''acute-phase response.'' Elevation of core temperature is certainly part of the acute-phase response, and cytokines that rais e core temperature in pathologic states are some of the same cytokines that account for other manifestations of the acute-phase response. Th is article examines fever as a past of the acute-phase reaction and th e role of cytokines in thermoregulation.