DIFFERENT EFFECTS OF ACUTE ADMINISTRATION OF AMINOPHYLLINE AND NITROGLYCERIN ON EXERCISE CAPACITY IN PATIENTS WITH SYNDROME-X

Authors
RADICE M GIUDICI V PUSINERI E BREGHI L NICOLI T PECI P GIANI P DEAMBROGGI L
Citation
M. Radice et al., DIFFERENT EFFECTS OF ACUTE ADMINISTRATION OF AMINOPHYLLINE AND NITROGLYCERIN ON EXERCISE CAPACITY IN PATIENTS WITH SYNDROME-X, The American journal of cardiology, 78(1), 1996, pp. 88
Citations number
NO
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
The American journal of cardiology → ACNP
ISSN journal
00029149
Volume
78
Issue
1
Year of publication
1996
Database
ISI
SICI code
0002-9149(1996)78:1<88:DEOAAO>2.0.ZU;2-C
Abstract
To investigate the effects of the acute administration of aminophyllin e and nitroglycerin on effort ischemia, 20 patients with syndrome X un derwent 3 bicycle exercise tests after sublingual nitroglycerin (0.3 m g) and after 90 minutes of oral administration of aminophylline (400 m g). Compared with the basal test, only aminophylline induced a signifi cant increase in the time to ischemic threshold and to angina; these f indings support the potential therapeutic role of this adenosine recep tor blocking agents and suggest a possible role of ''steal phenomenon' ' in the pathogenesis of effort angina in patients with syndrome X.