IDENTIFICATION AND CHROMOSOMAL LOCALIZATION OF ATM, THE MOUSE HOMOLOGOF THE ATAXIA-TELANGIECTASIA GENE

Atm, the mouse homolog of the human ATM gene defective in ataxia-telan giectasia (A-T), has been identified, The entire coding sequence of th e Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein, Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybri dization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromos ome 11q22-q23. (C) 1996 Academic Press, Inc.