A NEW REGION OF CONSERVATION IS DEFINED BETWEEN HUMAN AND MOUSE X-CHROMOSOMES

Comparative mapping of the X chromosome in eutherian mammals has revea led distinct regions of conservation as well as evolutionary rearrange ments between human and mouse. Recently, we and others mapped the muri ne homologue of CLCN4 (Chloride channel 4) to band F4 of the X chromos ome in Mus spretus but to chromosome 7 in laboratory strains. We now r eport the mapping of the murine homologues of APXL (Apical protein Xen opus laevis-like) and OA1 (Ocular albinism type I), two genes that are located on the human X chromosome at band p22.3 and in close proximit y to CLCN4, Interestingly, Oa1 and Apxl map to bands F2-F3 in both IM. spretus and the laboratory strain C57BL/6J, defining a new rearrangem ent between human and mouse X chromosomes. (C) 1996 Academic Press, In c.