HUMAN CANCERS DETECTED BY PROTON MRS AND CHEMICAL-SHIFT IMAGING EX-VIVO

Proton magnetic resonance spectroscopy (H-1 MRS) has the potential to become a diagnostic adjunct for the detection and grading of human neo plastic disease. This paper describes the use of proton MRS to documen t changes arising in the lipid chemistry of biopsies arising from the human uterine cervix, thyroid and colon and demonstrates the diagnosti c power of ex vivo spectroscopy. Proton chemical shift imaging (CSI) i s further used to determine the spatial location of lipid changes in e x vivo human biopsy specimens and provides insight into the chemistry of neoplastic transformation.