ESCHERICHIA-COLI - EVOLUTION OF RESISTANC E TO URINARY ANTIBIOTICS INCLUDING FOSFOMYCIN IN-HOSPITAL (11816 STRAINS, 1991-1995)

Escherichia coli is the major species of Gram negative bacilli recover ed from various specimens including urine and blood culture. The susce ptibility of 11 816 strains to various antibiotics including fosfomyci n and fluoroquinolones was determined by the agar diffusion method. Th e frequency of resistance appeared similar when compared between strai ns from various sites but greatly variable according to the antibiotic examined. The frequency of resistance to fosfomycin was the lowest an d highly stable unlike to other antibiotics such as fluoroquinolones.