Small non-cleaved cell lymphoma is one of the most rapidly growing mal
ignancies and in children is highly curable. However, in adults, the d
isease is disseminated in approximately one half of the patients, and
with standard chemotherapy used for lymphoma, is less curable than it
is in children, especially in patients presenting with bone marrow inv
olvement. However, recent developments in clinical management using in
tensive dose therapy for this disease have improved the eventual outco
me for these patients. This review focuses on some of these improvemen
ts.