AGGREGATE BREAKAGE OF THE PARTICLES WITH BIOSPECIFIC INTERACTION IN ASHEAR-FLOW

Authors
POTANIN AA VERKHUSHA VV MULLER VM
Citation
Aa. Potanin et al., AGGREGATE BREAKAGE OF THE PARTICLES WITH BIOSPECIFIC INTERACTION IN ASHEAR-FLOW, Colloid journal of the Russian Academy of Sciences, 58(3), 1996, pp. 355-362
Citations number
22
Categorie Soggetti
Chemistry Physical
Journal title
Colloid journal of the Russian Academy of Sciences → ACNP
ISSN journal
1061933X
Volume
58
Issue
3
Year of publication
1996
Pages
355 - 362
Database
ISI
SICI code
1061-933X(1996)58:3<355:ABOTPW>2.0.ZU;2-B
Abstract
Disaggregation of biospecifically interacting particles in a shear flo w was theoretically investigated based on the kinetic model of the bre akage of ligand-receptor bonds. It was assumed that a large particle a ggregate is broken as a result of rupture of the particle chain where portions of aggregate hold together. This theoretical model was shown to describe well the obtained experimental dependences of the sizes of stable aggregates consisting of the particles of latex immunoconjugat es and blood platelets on shear rate.