CD30-POSITIVE T-CELL LYMPHOMA OF THE INTESTINE, COMPLICATING ULCERATIVE-COLITIS

Large cell lymphoma with massive necrosis and a phagocytic reaction (m alignant histiocytosis-type lymphoma) occurred multifocally in the sma ll and large Intestine of a 52 year old male, who had suffered from ul cerative colitis of a pancolonic type for 2 years. After total colecto my and partial jejunectomy, the tumor recurred repeatedly during the s ubsequent 3-year period. He died of massive intestinal hemorrhage with mild regional lymph nodal involvement. Surface marker studies disclos ed CD4/CD8-double negative and CD30(+) T cell features. CD3 was weakly expressed. Epstein-Barr virus infection was not identified. The relat ionship of this neoplasm with 'enteropathy-associated T cell lymphoma' and intestinal Ki-1 lymphoma is discussed.