This paper discusses the effects of national systems of innovation on
organizational learning by companies, and how this affects industrial
structure. The analysis focuses specifically on the industrial respons
e by both large, existing companies and new small firms to the opportu
nities offered by biotechnology, and how far government policy and oth
er factors have shaped the different patterns of industrial developmen
t which have evolved in the US and the UK. Availability of venture cap
ital investment in the science base and national culture are found to
be important factors which explain the different initial patterns of c
ommercialization which emerged in the two countries. Evidence of consi
derable learning by British organizations leads to the conclusion that
, as biotechnology matures, industrial structure in the two countries
will converge. Copyright (C) 1996 Elsevier Science Ltd