LARGE-SCALE SYNTHESIS OF A LEWIS-B TETRASACCHARIDE DERIVATIVE, ITS ACRYLAMIDE COPOLYMER, AND RELATED DISACCHARIDES AND TRISACCHARIDES FOR USE IN ADHESION INHIBITION STUDIES WITH HELICOBACTER-PYLORI

The 2-aminoethyl glycoside of -(1-->4)]-2-acetamido-2-deoxy-beta-D-glu copyranose (Lewis B tetrasaccharide) was synthesized on a large scale and acryloylated with acryloyl chloride. The obtained oligosaccharide 2-acrylamidoethyl glycoside was then copolymerized with acrylamide to form a water-soluble, high molecular weight polymer, suitable for use in adhesion inhibition studies with Helicobacter pylori. Also synthesi zed were the corresponding derivatives of l-(1-->3)-2-acetamido-2-deox y-beta-D-glucopyranose and ha-L-fucopyranosyl-(1-->2)-beta-D-galactopy ranose.