DIFFUSE PLAQUES IN THE CEREBELLUM AND CORPUS STRIATUM IN DOWNS-SYNDROME CONTAIN AMYLOID-BETA PROTEIN (A-BETA) ONLY IN THE FORM OF A-BETA(42(43))

The diffuse amyloid (A beta) plaques of the cerebellum and corpus stri atum were examined in 32 patients with Down's syndrome, ranging in age from 9 to 71 years, using the end-specific monoclonal antibodies BA27 and BC05 to detect A beta species terminating at amino acids 40 and 4 2(43) respectively. When present, the diffuse plaques of both regions contained only A beta(42(43)) at all ages. A beta(40) was, however, pr esent along with A beta(42(43)) in the few cored plaques that were occ asionally present in the Purkinje and molecular cell layers of the cer ebellum of some of the more elderly patients. It is concluded that dif fuse plaques of the cerebellum and striatum contain only A beta(42(43) ) and that, in contrast to those of the cerebral cortex, these do not 'mature' during their lifetime into A beta(40) containing plaques. (C) 1996 Academic Press Limited.