SERUM HAPTOGLOBIN CONCENTRATION IN GROWING SWINE AFTER INTRANASAL CHALLENGE WITH BORDETELLA-BRONCHISEPTICA AND TOXIGENIC PASTEURELLA-MULTOCIDA TYPE-D

The acute phase reaction, in association with progressive atrophic rhi nitis (AR), was monitored for 3 wk using serum haptoglobin (HPT) quant ification in thirty-six, 15 kg swine after intranasal challenge with v arying doses of Pasteurella multocida type D (toxigenic strain) and Bo rdetella bronchiseptica. The challenge doses were administered alone o r in combination with pis divided into 9 isolated treatment groups, In creasing doses of B. bronchiseptica were associated with lower serum H PT (P < 0.05), whereas increasing doses of P, multocida tended to incr ease serum HPT (0.05 < P < 0.10), Significant and positive correlation of mean HPT and AK score was found in these pigs; increased AR scores were associated with elevated mean HPT concentration (r = 0.41, P < 0 .01), A significant interaction between P. multocida and B. bronchisep tica, dose indicated that increasing the dose of B. bronchiseptica, fo r a fixed P. multocida dose, was associated with less AR (P < 0.05), T he AR scores were greater in pigs given P. multocida, than B. bronchis eptica alone. These results indicate that a complex interaction betwee n Pasteurella multocida and Bordetella bronchiseptica causes progressi ve atrophic rhinitis and alters serum HPT concentration in swine.