S. Uetsuji et al., GALLBLADDER CANCER WITH A LOW JUNCTION OF THE CYSTIC DUCT OR AN ANOMALOUS PANCREATICOBILIARY JUNCTION, European journal of gastroenterology & hepatology, 8(12), 1996, pp. 1213-1217
Objective: To evaluate conditions similar to those of carcinogenesis o
f the gallbladder between the gallbladder with a low junction of the c
ystic duct (LJCD) and an anomalous pancreaticobiliary junction (APBJ).
Design: Retrospective and clinicopathological analysis of patients wi
th gallbladder carcinoma. Setting: First Department of Surgery, Kansai
Medical University. Patients: Examination of 47 patients (7 men and 4
0 women; average age: 67.8 years) with gallbladder carcinoma revealed
7 patients (14.9%; 1 man and 6 women; average age: 67.8 years) with LJ
CD and 6 patients (12.8%; 6 women; average age: 60.3 years) with APBJ.
Methods: Clinical findings in both groups were compared with those of
the 34 patients who remained after exclusion of the data of the above
7 patients with LJCD and 6 patients with APBJ. The data of the three
groups were examined by the chi(2) test at the 5% level of significanc
e. Results: Most of the gallbladder cancer patients with LJCD or APBJ
had gallstones. The biliary amylase levels determined in the gallbladd
er of patients with LJCD or APBJ were remarkably high. Conclusion: The
results indicate that patients with LJCD or APBJ are more likely to d
evelop carcinoma of the gallbladder. The factors responsible for carci
nogenesis may be alteration of the bile content due to reflux of pancr
eatic enzymes through the LJCD or APBJ, and mechanical irritation due
to gallstones. Therefore, these pathological conditions in patients wi
th LJCD are similar to those experienced in patients with APBJ.