The Simon effect was studied using ERPs and the lateralized readiness
potential (LRP). In Experiment 1, visual stimuli requiring left or rig
ht hand responses were presented at either side of fixation. In Experi
ment 2, the empty side was occupied by a distracter. Spatial S-R incom
patibility delayed P300 latency in both experiments, as predicted by p
erceptual interference accounts of the Simon effect. However, the LRP
results were not conclusive. The lateralized presentation of visual st
imuli (Experiment 1) or targets (Experiment 2) produced a posterior ER
P hemispheric asymmetry that spread to central electrodes and obscured
the early development of the LRP. Experiment 3 avoided the problem by
presenting the stimuli in the vertical meridian, and the LRP showed s
igns of incorrect response preparation in incompatible trials, in agre
ement with response-interference models. Both perceptual and response
interference may be present in the Simon effect.