LYMPHOCYTE MIGRATION INTO TISSUE - THE PARADIGM DERIVED FROM CD4 SUBSETS

Authors
BRADLEY LM WATSON SR
Citation
Lm. Bradley et Sr. Watson, LYMPHOCYTE MIGRATION INTO TISSUE - THE PARADIGM DERIVED FROM CD4 SUBSETS, Current opinion in immunology, 8(3), 1996, pp. 312-320
Citations number
64
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
8
Issue
3
Year of publication
1996
Pages
312 - 320
Database
ISI
SICI code
0952-7915(1996)8:3<312:LMIT-T>2.0.ZU;2-J
Abstract
The appropriate recirculation and migration of naive, effector and mem ory T cells into inflamed tissue are precisely controlled by adhesive interactions with vascular endothelium. Analyses of CD4 lymphocytes ha ve indicated that naive and antigen-experienced cells exhibit distinct ive patterns of homing and recirculation, and that subsets of cells pr eferentially localize in different anatomical locations as a consequen ce of previous antigen exposure and differences in adhesion receptor u sage.