ROLE OF FAS-MEDIATED CELL-DEATH IN THE REGULATION OF IMMUNE-RESPONSES

Authors
VANPARIJS L ABBAS AK
Citation
L. Vanparijs et Ak. Abbas, ROLE OF FAS-MEDIATED CELL-DEATH IN THE REGULATION OF IMMUNE-RESPONSES, Current opinion in immunology, 8(3), 1996, pp. 355-361
Citations number
70
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
8
Issue
3
Year of publication
1996
Pages
355 - 361
Database
ISI
SICI code
0952-7915(1996)8:3<355:ROFCIT>2.0.ZU;2-R
Abstract
Interaction of the cell-surface molecule Pas (CD95 APO-1) with its spe cific ligand triggers apoptotic death of T and B lymphocytes. This pat hway is important for eliminating self-reactive lymphocytes and thus p reventing autoimmunity. Pas is also involved in controlling injurious lymphocyte reactions in immunologically 'privileged' tissues, and may provide a strategy for reducing graft rejection.