MITOCHONDRIAL BIOGENESIS IN SKELETAL-MUSCLE IN RESPONSE TO ENDURANCE EXERCISES

Repeated bouts of endurance exercise stimulates mitochondrial biogenes is in skeletal muscle. The synthesis of mitochondrial proteins involve s a coordinated expression of both nuclear and mitochondrial genes. Du ring this process, multiples sites of regulation have been identified at the transcriptional and translational levels. After their synthesis , mitochondrial proteins originating from the nuclear genome are impor ted into newly synthesized preexisting membranes and directed to one o f the four mitochondrial subcompartments. The detailed mechanisms of t he endurance training-induced mitochondrial biogenesis are still poorl y understood. In particular, much work is needed to identify the molec ular signals able to stimulate and coordinate the expression of mitoch ondrial proteins in response to endurance training. This will be a gre at help in the future to understand clearly the intimate mechanisms of mitochondrial biogenesis in skeletal muscle and the factors involved in endurance exercise performance.