SENSITIVITY OF SUP35 AND SUP45 SUPPRESSOR MUTANTS IN SACCHAROMYCES-CEREVISIAE TO THE ANTI-MICROTUBULE DRUG BENOMYL

SUP35 and SUP45 genes determine the accuracy of translation at the sta ge of termination. We present indirect evidence indicating that these genes may also control some cellular process mediated by microtubules. A majority of sup35 and sup45 suppressor mutations confer supersensit ivity to benomyl, the drug which de-polymerizes microtubules. In addit ion, data correlating phenotypic manifestations of sup45 suppressor mu tations, involving sensitivity to benomyl, respiratory deficiency and a suppressor effect, are also presented.