MONITORING CP-93,393 REACTION MIXTURES BY FLOW-INJECTION ANALYSIS MASS-SPECTROMETRY

CP-93,393 is a drug candidate at Pfizer. Flow-injection analysis-mass spectrometry (FIA-MS) was used to monitor reaction completion for CP-9 3,393 reaction mixtures. FIA-MS provides essentially instantaneous res ults, is relatively simple to operate, and is a universal system that can be used to monitor any reaction as long as the product has a molec ular weight that differs from the molecular weights of the reactants. The mass spectrometer for these studies employed atmospheric pressure chemical ionization. Samples were introduced into the mass spectromete r with a flowing stream of solvent.