THE EFFECT OF A PULSED MAGNETIC-FIELD AND THAT OF METHYL-SILANE TRIOLON GALACTOSAMINE-INDUCED HEPATITIS AMONG RATS

Liver cell necrosis was induced in rats by a galactosamine injection, Cell death was due to an increase of Ca++ intracellular levels and was also under the control of genes, Rats were then either exposed or not to a 6 mT 100 HZ pulsed magnetic field (PMF) and they either received or not methylsilane-triol injections, Animals were sacrificed twenty- seven hours after a galactosamine injection, On the one hand it appear ed from transaminase levels that the PMF increased the number of anima ls which were sensitized to galactosamine but decreased transaminase l evels, On the other hand PMF decreased the protective effect of MST ag ainst galactosamine, We may suggest that PMF should be considered as a n additional cellular signal received through genes which would determ ine the evolution towards or against apoptosis according to the age of the cell itself but also to the Ca++ intracellular level.