EVALUATION OF THE EFFICACY AND TOLERABILITY OF 4 DIFFERENT THERAPEUTIC REGIMENS FOR THE HELICOBACTER-PYLORI ERADICATION

The aim of our study is to evaluate the efficacy and tolerability of f our different therapeutic regimens for Helicobacter pylori eradication , One-hundred and thirty-two consecutive patients suffering from eithe r peptic ulcer or non-ulcer dyspepsia, with Helicobacter pylori infect ion, were allocated to one of the following 4 groups with different th erapeutic regimens: A) omeprazole 20 mg bid for 14 days/amoxycillin 10 00 mg bid for 14 days/tinidazole 500 mg bid for 14 days (30 patients, 13 with peptic ulcer); B) omeprazole 20 mg bid for 14 days/amoxycillin 1000 mg bid for 14 days (41 patients, 23 with peptic ulcer); C) omepr azole 20 mg bid for 14 days/azithromycin 500 mg/day for 3 days for 2 c onsecutive weeks (25 patients, 12 with peptic ulcer); D) omeprazole 20 mg/day for 7 days/clarithromycin 250 mg bid for 7 days/tinidazole 500 mg bid for 7 days/(36 patients, f4 with peptic ulcer), The Helicobact er pylori status was evaluated by means of histology, culture and urea se test, at entry and 8 weeks after treatment, 2 group A, B and D pati ents, 1 D patient didn't complete the treatment, In evaluable patients , the Helicobacter pylori eradication was obtained in 24 patients of g roup ri (85.71%), in 23 of group B (58.98%), in 11 of group C (45.83%) and in 24 of group D (70.58%), On intention-to-treat analysis, Helico bacter pylori eradication was 80% in group A, 56.09% in group B, 44% i n group D and 66.67% in group D, Sideeffects occurred in 6 patients of group A (20.68%), in 5 of group B (12.5%), in 3 group D (8.82%) and n one of group C, In conclusion, triple therapy with omeprazole/clarithr o-mycin/tinidazole is better for cost/benefit ratio; omeprazole/amoxyc illin/tinidazole is more effective than others regimens in the Helicob acter pylori eradication, but causes more side effects; double therapy with omeprazole/azithromycin is the most tolerable and the least effi cacy for Helicobacter pylori eradication.