Medical therapy in ectopic and ovarian pregnancies in particular, can
be a valid alternative to the surgical approach, since it can guarante
e the reproductive function in a better way. More and more attempts wi
th methotrexate, which can induce the death of both embryo and trophob
iastic tissue, are being made. Both its administration and results are
still under debate. In our case histories, three clinical cases are r
eported and two of them proved to be successful. In our opinion, apart
from the method of administration, the pre-requisites for a therapeut
ic success are: a small ovular sac (max 30 mm), no echographically vis
ible embryo which corresponds to a six-week pregnancy. The success of
the therapy, therefore, depends on the precociousness of the diagnosis
.