ANTI-PSEUDOMONAL ACTIVITY OF COLLAGEN SPONGE WITH LIPOSOMAL POLYMYXIN-B

An antibiotic delivery system has been developed using collagen sponge with liposome-encapsulated polymyxin B. Superficial, non-lethal infec tion was produced in mice by injecting Pseudomonas aeruginosa into the skin windows, Wounds were dressed with collagen sponge containing lip osomal polymyxin B or containing empty liposomes (with PBS) as a contr ol. Single dose of topically applied collagen sponge with encapsulated polymyxin B decreased bacterial cell number as compared to the contro l, Finally, after 8 days of experiment, the number of bacterial coloni es dropped below 10(4) per biopsy, Presented polymyxin B delivery syst em offers potential clinical advantages. (C) 1996 The Italian Pharmaco logical Society