HISTOPATHOLOGICAL CHANGES IN RABBIT UTERUS CARCINOMA AFTER TRANSCATHETER ARTERIAL EMBOLIZATION USING CISPLATIN

The effects of chemoembolization with cisplatin on gynecological malig nancy were investigated using rabbit uterine tumors, A group of 20 rab bits were subjected to inoculation of the uterus with 5x10(7) VX2 carc inoma cells and 4 weeks later were divided into four groups, each cons isting of five rabbits: an untreated control group, a group given cisp latin intraarterially (IA), a group subjected to transcatheter arteria l embolization (TAE) with Gelfoam particles and a group subjected to t ranscatheter chemoembolization (TACE) with Gelfoam particles plus 1 mg /kg cisplatin. All groups were examined histologically 2 days after tr eatment. The untreated control group was further investigated 4 weeks after inoculation. In the untreated control group, the tumor cell nucl ei varied in size and were irregular in form, and multiple nuclei and nuclear division were also observed. No necrotic zones were found up t o 4 weeks after inoculation, The IA group showed no necrosis, but a fe w apoptotic cells were scattered throughout the tumor. In the TAE grou p, necrosis was observed in the center of the tumors, but proliferatin g cells persisted at the periphery. In the TACE group, necrosis was ob served in the central part with many apoptotic cells surrounding the n ecrotic region in layers. The proliferating cell nuclear: antigen (PCN A) index was 95.88% in the untreated control group, 86.6% in the IA gr oup, and 8.62% in the TACE group, indicating a significant reduction i n cell proliferation in the TACE group. These findings suggest that TA CE results in more effective cytotoxicity than the other two treatment s in uterine cancer tumor transplants.