LONG-TERM RESULTS OF SHORT SEGMENTAL SYNGENEIC SMALL-INTESTINAL TRANSPLANTATION - COMPARISON OF JEJUNAL AND ILEAL GRAFTS

A short-segment intestinal graft is favorable to reduce the rate of re jection and the incidence of graft-versus-host disease in recipients o f small intestine transplantation. To determine whether a jejunal or a n ileal graft is preferable with respect to intestinal morphology and function, syngeneic two-step small intestinal transplantations were pe rformed using male Lewis rats (RT1(1)). They were divided into two gro ups according to the small intestine donor site (group 1 received 10 c m of jejunum; group 2 received 10 cm of ileum). There was no significa nt difference in the survival rate or weight gain between the two grou ps. Nearly all the hematologic findings, serum nutritional parameters, and results of liver function tests were normal for both groups. The only difference was that the serum total bile acid level was significa ntly higher in group 2. Fifty weeks after transplantation, the graft m ucosa showed normal architecture, with adaptive hyperplasia of villi a nd crypt noted through histological study. The villus height of group 1 was 595 +/- 64 mu m (control, 452 +/- 67 mu m); that of group 2 was 732 +/- 53 mu m (control, 217 +/- 20 mu m). The crypt depth of group 1 was 228 +/- 35 mu m (control, 165 +/- 24 mu m); that of group 2 was 3 20 +/- 19 mu m (control, 102 +/- 19 mu m). These compensatory changes were more pronounced in group 2. The authors conclude that, on the bas is of long-term functional capacity, there was no significant differen ce between jejunal and ileal grafts, and that both segments were suita ble for transplantation. However, the ileal graft was considered to be better with respect to morphological adaptation. Copyright (C) 1996 b y W.B. Saunders Company