Mo. Rawashdeh et Ha. Majeed, FAMILIAL MEDITERRANEAN FEVER IN ARAB CHILDREN - THE HIGH PREVALENCE AND GENE-FREQUENCY, European journal of pediatrics, 155(7), 1996, pp. 540-544
Over a period of 3 years, 192 children with familial Mediterranean fev
er were prospectively studied. Of these, 106 (55%) were girls and 86 (
45%) were boys. The prevalence was 1:2600 children with a gene frequen
cy of 1:50. The age at onset ranged between 4 months and 16 years. Of
these patients 24% started their illness below the age of 2 years and
88% were symptomatic before the age of 10 years; 82% had recurrent abd
ominal pain, 43% had pleurisy, 37% had arthritis, 15% had cutaneous ma
nifestations, 12% had splenomegaly and 4% had hepatomegaly. The presen
ting symptoms were abdominal pain in 51%, unilateral chest pain in 23%
and arthritis in 26%. The family history was positive in 62%. Of 12 a
ffected families 19 members had/have renal failure and amyloidosis was
confirmed in 7 patients. Conclusion Our data show a high prevalence o
f familial Mediterranean fever and a high gene frequency in Arab child
ren similar to that reported in Jews and Armenians.