BRONCHIAL CONSTRICTION AFTER NEBULIZED TOBRAMYCIN PREPARATIONS AND SALINE IN PATIENTS WITH CYSTIC-FIBROSIS

Citation
Wh. Nikolaizik et al., BRONCHIAL CONSTRICTION AFTER NEBULIZED TOBRAMYCIN PREPARATIONS AND SALINE IN PATIENTS WITH CYSTIC-FIBROSIS, European journal of pediatrics, 155(7), 1996, pp. 608-611
Citations number
10
Categorie Soggetti
Pediatrics
ISSN journal
03406199
Volume
155
Issue
7
Year of publication
1996
Pages
608 - 611
Database
ISI
SICI code
0340-6199(1996)155:7<608:BCANTP>2.0.ZU;2-N
Abstract
To assess the airway response to inhaled tobramycin we measured flow v olume curves in 12 patients with cystic fibrosis. Immediately and/or 2 min after tobramycin inhalations there was a significant fall in lung function regardless of the concentration used; isotonic saline caused similar obstruction but not a complete cessation of peripheral airflo ws. The baseline oxygen saturation was significantly correlated with t he fall in lung function. Ten minutes after inhalation lung function t ests returned to baseline values. Conclusion As salbutamol could signi ficantly reduce airway obstruction tobramycin should always be inhaled in combination with a bronchodilator.