Wh. Nikolaizik et al., BRONCHIAL CONSTRICTION AFTER NEBULIZED TOBRAMYCIN PREPARATIONS AND SALINE IN PATIENTS WITH CYSTIC-FIBROSIS, European journal of pediatrics, 155(7), 1996, pp. 608-611
To assess the airway response to inhaled tobramycin we measured flow v
olume curves in 12 patients with cystic fibrosis. Immediately and/or 2
min after tobramycin inhalations there was a significant fall in lung
function regardless of the concentration used; isotonic saline caused
similar obstruction but not a complete cessation of peripheral airflo
ws. The baseline oxygen saturation was significantly correlated with t
he fall in lung function. Ten minutes after inhalation lung function t
ests returned to baseline values. Conclusion As salbutamol could signi
ficantly reduce airway obstruction tobramycin should always be inhaled
in combination with a bronchodilator.