HISTAMINE-RECEPTORS AND BIOEFFECTS ON CLONAL PARATHYROID ENDOTHELIAL-CELLS

Authors
FREDIANI U BENVENUTI S MASI L TANINI AL BRANDI ML
Citation
U. Frediani et al., HISTAMINE-RECEPTORS AND BIOEFFECTS ON CLONAL PARATHYROID ENDOTHELIAL-CELLS, Journal of endocrinological investigation, 19(5), 1996, pp. 298-303
Citations number
36
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Journal of endocrinological investigation → ACNP
ISSN journal
03914097
Volume
19
Issue
5
Year of publication
1996
Pages
298 - 303
Database
ISI
SICI code
0391-4097(1996)19:5<298:HABOCP>2.0.ZU;2-5
Abstract
Using a clonal line of bovine parathyroid endothelial cells (BPE-1) we defined the presence on these cells of a histamine H-2 receptor and c haracterized its pharmacological properties. Interaction of histamine with its receptor induced an increase of cAMP accumulation in a dose- and time-dependent fashion. This effect appears unique for parathyroid endothelial cells, in fact, clonal parathyroid epithelial cells did n ot exhibit a similar response. No effect of histamine was observed on BPE-1 cell proliferation.