The place of beta-agonist drug therapy in the management of asthma has
been a major source of debate and therapeutic uncertainty during the
1990s. The possible adverse effects of these drugs on control of asthm
a and lung function are reviewed, and potential mechanisms for these e
ffects are discussed. A hypothesis is proposed linking epidemiologic t
rends in asthma morbidity and mortality rates to beta-agonist drug use
.