Airway compromise is the most common cause of death and severe morbidi
ty in acutely ill and injured children. Rapid-sequence intubation (RSI
) is a technique for emergency airway control designed to maximize suc
cessful endotracheal intubation while minimizing the adverse physiolog
ic effects of this procedure. RSI requires familiarity with patient ev
aluation, airway-management techniques, sedation agents, neuromuscular
blocking agents, additional adjunctive agents, and postintubation man
agement techniques. Emergency physicians should use RSI techniques in
the endotracheal intubation of critically iii children.