CHEMOTHERAPY FOR LYMPHATIC METASTATIC GYNECOLOGIC CANCER VIA PELVIC RETROPERITONEAL CANNULATION - A PRELIMINARY-REPORT

The feasibility of chemotherapy for lymphatic metastatic gynecologic c ancer via pelvic retroperitoneal cannulation was preliminarily studied . In 25 patients with gynecologic cancer 5-FU was safely allocated by cannulation to the pelvic retroperitoneal space including the external iliac, internal iliac, obturator, and deep inguinal and most of the c ommon iliac lymph nodes. The 5-FU concentration in the lymph nodes on the injection side was 2-10 times that on the control side (P <0.01). In 4 patients with nodal metastasis on the injection side, most cancer cells showed degeneration and necrosis. No severe complications or ad verse effects were observed. The results suggested that the cannulatio n be used to treat the lymphatic metastasis of gynecologic cancer. (C) 1996 Academic Press, Inc.