DIFFERENT CHARACTERISTICS OF RENAL EXCRETION OF POTASSIUM AND MAGNESIUM AFTER APPLICATION OF DIMETHYLAMINO-HYDROXYPROPOXYTRIAMTERENE (RPH-2823) IN RATS

Authors
PRIEWER H ULLRICH F KLEINSORGE D KNAUF H MUTSCHLER E
Citation
H. Priewer et al., DIFFERENT CHARACTERISTICS OF RENAL EXCRETION OF POTASSIUM AND MAGNESIUM AFTER APPLICATION OF DIMETHYLAMINO-HYDROXYPROPOXYTRIAMTERENE (RPH-2823) IN RATS, Magnesium-Bulletin, 18(2), 1996, pp. 31-33
Citations number
16
Categorie Soggetti
Biology
Journal title
Magnesium-Bulletin → ACNP
ISSN journal
0172908X
Volume
18
Issue
2
Year of publication
1996
Pages
31 - 33
Database
ISI
SICI code
0172-908X(1996)18:2<31:DCOREO>2.0.ZU;2-4
Abstract
In the present paper further evidence is provided that the transportin g systems for Na+, K+ and Mg2+ in the late distal tubule of the kidney in rats are different and can be influenced independently from each o ther. By elevating the dose, RPH 2823 causes a strong increase of the Na+ excretion whereas the Mg2+ excretion is reduced dose-dependently. In contrast to the effects on magnesium excretion the kaliuresis is de creased at low doses of RPH 2823 but reincreases significantly with hi gher doses.