THE MOLECULAR-BASIS AND CLINICAL CHARACTERISTICS OF MATERNALLY INHERITED DIABETES AND DEAFNESS (MIDD), A RECENTLY RECOGNIZED DIABETIC SUBTYPE

Authors
MAASSEN JA JANSEN JJ KADOWAKI T VANDENOUWELAND JMW THART LM LEMKES HHPJ
Citation
Ja. Maassen et al., THE MOLECULAR-BASIS AND CLINICAL CHARACTERISTICS OF MATERNALLY INHERITED DIABETES AND DEAFNESS (MIDD), A RECENTLY RECOGNIZED DIABETIC SUBTYPE, EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 104(3), 1996, pp. 205-211
Citations number
41
Categorie Soggetti
Endocrynology & Metabolism
Journal title
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES → ACNP
ISSN journal
09477349
Volume
104
Issue
3
Year of publication
1996
Pages
205 - 211
Database
ISI
SICI code
0947-7349(1996)104:3<205:TMACCO>2.0.ZU;2-3
Abstract
Diabetes mellitus comprises a number of diseases with hyperglycemia as hallmark. Currently, multiple genetic factors are being recognized wh ich contribute to the development of diabetes or which may modulate it s clinical expression. This review presents an overview of our current knowledge on a diabetic subtype which associates with a single mutati on in mitochondrial DNA. Based on the triad of Maternal Inheritance, D iabetes and Deafness we propose the name Maternally Inherited Diabetes and Deafness (MIDD) for this syndrome. In Northwestern Europe MIDD af fects approximately 1.3% of all diabetic individuals.