AN ECONOMIC-EVALUATION OF ORAL COMPARED WITH INTRAVENOUS GANCICLOVIR FOR MAINTENANCE TREATMENT OF NEWLY-DIAGNOSED CYTOMEGALOVIRUS RETINITISIN AIDS PATIENTS

This prospective, clinical economic study was done to determine the co st impact of oral compared with intravenous (IV) ganciclovir for the m aintenance treatment of newly diagnosed cytomegalovirus (CMV) retiniti s in patients with acquired immunodeficiency syndrome (AIDS), Efficacy and safety data were extracted from a trial of oral and IV ganciclovi r. Medical care utilization and reimbursement data were obtained from the clinical trial, a survey of home care and nursing companies, an 11 -member physician panel, and a Medicaid cost database. The primary out come measures were time to first retinitis progression and associated direct medical care expenditures. Nonmedical costs and quality-of-life benefits were not considered. Based on masked evaluation of retinal p hotographs, the Kaplan-Meier mean time to first progression was 62 day s for IV ganciclovir and 57 days for oral ganciclovir (a nonsignifican t difference). The expected mean cost of treatment for IV ganciclovir was significantly different at $8587.00 compared with $4938.00 for ora l treatment. Sensitivity analysis using funduscopically determined mea n time to first progression showed similar cost savings. We concluded that oral ganciclovir is a cost-saving alternative to IV ganciclovir f or the maintenance treatment of AIDS patients with newly diagnosed CMV retinitis. Cost differences are attributable to reduced home care exp enditures and lower incidence and costs of treating major adverse even ts in the oral treatment group.